Federal Member for Bendigo, Lisa Chesters, is seeking an urgent meeting with La Trobe University to discuss the impact of the announcement on Friday to cut 350 full-time jobs, including some from the Bendigo campus.
It is unclear how many Bendigo jobs will be cut.
"It's too early to know where these changes will occur and who will be affected so that's why I'm seeking an urgent meeting," Ms Chesters said.
"I'll be campaigning to see as many Bendigo jobs saved as possible because our campus is doing really well.”
Ms Chesters said losing 350 jobs from any organisation was a devastating blow.
"I understand why the university has made this move now because the Liberal National government has flagged further cuts in the upcoming budget," Ms Chesters said.
"I've already spoken with the campus director and I've offered my assistance and support in any way I can.
"I'm seeking a meeting with La Trobe Vice Chancellor Professor John Dewar to discuss the impacts of these redundancies and changes to the Bendigo La Trobe campus.
"I'm also planning to meet with students and staff representatives because I'm concerned that any reduction in staff could affect teaching and course delivery and quality.”
Ms Chesters said job cuts would have a ripple-effect within the Bendigo community.
"We can't afford to let these wages be withdrawn from our local economy," she said.
"There's a knock-on effect - those wages will not be spent locally in our shops and restaurants.
"What is clear is that while Tony Abbott continues to be our Prime Minister, no job or industry is safe."